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Addressing this issue as a multi-criteria decision problem, the authors integrate the concept of the “Innovative Helix” and its modifications, which are describing the interaction of science, government and business, as well as formal methods of game theory and business simulation games as a basis for modeling the process of sustainable development in a spatial innovation and entrepreneurial ecosystem. In practical terms, also a first case study for Russia will be designed and set up for further discussion. • n is the number of players (groups); • Ri is the amount of resources available to player i, i = 1,, n; • m is the number of the innovative projects in the game; • CDminj, CDmaxj are the minimum and the maximum development costs, respectively, of innovative project j, j = 1,, m; • CIminj, CImaxj are the minimum and the maximum production and sales costs, respectively, of innovative project j; • ERj is the expected revenue from project j; • α is the investment return from a risk-free project. The purpose and interest of the article is to provide input for further discussion on these and other issues related to organizing and governing the interaction of key stakeholders in such arrangements. Granberg a g osnovi regionaljnoj ekonomiki 1. In real world situations, the innovations are accompanied by risk and uncertainty.

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